Junction 13 of the M65 at Nelson is due to be closed overnight for resurfacing, as part of a major project to boost economic development nears completion.
The junction will be closed from 10.30pm to 5am on April 26th and 27th, and from the 2nd - 5th of May, the 8th - 13th of May, and the 15th -19th of May.
A diversion will be in place via the A6068 and A682 in Barrowford, Nelson, and Colne, guiding traffic to the motorway at junction 14.
Work has taken place over the last year to create extra traffic capacity at the junction by modifying the layout of the two roundabouts at junction 13, with up to four traffic lanes in places.
Traffic lights have been added to the roundabout on the west side, with other minor improvements also improving vehicle capacity and providing safer pedestrian and cycle access.
While the junction is closed, road markings will fit in with the new design and allow traffic signals to operate.
The £1.5m scheme will reduce congestion and improve access to local development sites such as Barrowford Business Park, and improve connections to Nelson and Colne College, the town centre, and the A682 traffic corridor.
The resurfacing is one of a number of improvements being made along the M65 - known as the Hyndburn Burnley Pendle Growth Corridor - in a £12m programme.
With £8-worth of funding from the Lancashire Enterprise Partnership Growth Fund, £4m-worth of further contributions have come from Lancashire County Council; Burnley, Pendle, and Hyndburn borough councils; and the European and Regional Growth Fund.