Earby, winners in 1991, will face 2011 winners Ribblesdale Wanderers in the Ramsbottom Cup semi-finals after registering the highest total of the last eight ties.
Earby won the toss and decide to bat first on a rock-hard straw coloured wicket.
Chris Walton fell in the second over to one that kept low, but professional Fahid Rehman strode to the middle and batted with great control.
Matt Wilson raced to 31 off 25 balls before being caught behind off Chris Holt, and Aaron Pollard looked comfortable, adding 50 for the third wicket before he fell for 24. Danny Kegg hit a swift 30, including two massive sixes, before he went with the score on 169.
Richard Craddock replaced him and kept the score climbing well, and Rehman made his 50 off 80 balls but fell on 65.
Lee Parkinson hit a quickfire 26 off 25 balls, leaving Padiham chasing 261 for victory,
Padiham never looked comfortable from the start, and two wickets for Craddock had them at 11-2.
When Lee Parkinson took the first of his wickets, Padiham were wobbling at 29-3,
Parkinson continued chipping away with wickets, and Padiham professional Holt was the eighth wicket to fall with the score on a miserable 72.
Padiham were eventually all out for just 92, Parkinson finishing with 5-27.