After their 4-0 victory over Silsden in midweek, Colne netted another four goals on Saturday thanks to an impressive hat-trick by striker Danny Boyle.
The Reds made a bright start, with Mark Threlfall twice coming close to opening the scoring.
And on seven minutes Colne opened their account when Neil Stanfield’s cross picked out Boyle, who headed into the top corner.
On quarter-of-an-hour, Boyle almost added a second when, from a short corner, his shot from deep on the left beat Flixton keeper Jowsey but struck the bar.
Against the run of play, Flixton equalised thanks to a moment of brilliance from the league’s leading scorer Astley Mulholland, who was first to react to a free kick, and he swivelled round to unleash a rocket of a shot into the corner.
Undeterred, the Reds continued to dominate with their quick passing and good movement, and they looked certain to increase their lead when Sam Morris picked out Boyle unmarked at the far post, but with only Jowsey to beat, he pulled his shot wide.
But just before the break Flixton took the lead when the Reds lost possession in midfield and Mulholland was played through the middle to notch his 32nd goal of the season.
In the second half the Reds continued to knock the ball around confidently. Threlfall was denied by a good save by Jowsey, and then Jonathan Maylot had a good strike which flew narrowly wide.
And on 59 minutes Colne scored a well-deserved equaliser when Boyle nipped in between two defenders to glance a delightful cross by James Crorken into the bottom corner.
Flixton’s frustration was evident as the Reds continued to dominate, and on 70 minutes they were reduced to 10 men when James Russell received a second booking card for a lunging tackle on Morris.
Five minutes later Colne took the lead when Ben Bridson was brought down area and Boyle confidently converted the penalty.
In the final minute Jowsey lost possession of the ball near the corner flag and when the ball broke to Bridson, he blasted into the far corner to seal a convincing victory.
Tomorrow Colne entertain Runcorn Linnets at the XLCR Stadium before their return visit to Flixton on Wednesday.