Nelson have one point to show from their first two games back in the NWC Premier Division.
The First Division champions drew 1-1 at home to Runcorn Town on Saturday, before suffering a 3-0 defeat at Squires Gate on Tuesday night.
On Saturday, the Blues started the brighter, with Jonny Hession prominent, as he had a shot charged down, before being brought down for a free kick which Dan Mahoney wasted.
Captain Robert Grimes fed Peter Wright after a mazy run, and he drilled a left-foot shot straight at keeper Buckley Smith.
The keeper then brought Wright down in the area, and was lucky to only receive a yellow card. Wright took the kick and beat Smith low to his right.
The Blues had an escape when a free kick rebounded off the foot of the post, but they might have added to their lead before the break, Mahoney and Adnan Ahmed both testing Smith, while Wright sent an effort wide.
Runcorn started the second half in more determined mood , but Grimes had another opening, firing straight at Smith.
Mahoney then had an effort cleared off the line from a corner, and Hession had a penalty appeal turned down, before Runcorn snatched a late equaliser, when a fine cross from the right was turned in by Sean Breen.
On Tuesday night, Nelson started on the front foot as Gareth Peet went close, while Harry Dunn tried his luck from 30 yards at the other end.
Midway through the half, Squires Gate went in front as Jack Sowerby latched onto a throughball and slotted past Ben Woodhead in the Nelson goal.
Wright twice threatened with headers, sending a Peet cross swide, before connecting with a Mahoney free kick and forcing a save from Ben Fletcher.
Peet thought he might have had a penalty just before the break, but Gate netted a second two minutes from the interval as Sowerby drove at the Nelson defence before finding the corner of the net.
And Sowerby completed his hat-trick to kill Nelson off, picking himself up after being fouled to score from the spot.
Wright was denied a prnalty at the other end after appearing to be fouled as he shaped to shoot, but appeals were in vain.
Nelson are at AFC Liverpool tomorrow, before a derby clash at home to Barnoldswick Town on Tuesday night.