Colne will host derby rivals Nelson in the first round of the Worsley Cup on May 10th.
The sides have been drawn together at the Horsfield in the competition, which has been won for the last two seasons by Burnley.
The full draw is: Church v Ramsbottom; Colne v Nelson; Enfield v Todmorden; Haslingden v Burnley; Rawtenstall v Accrington; Rishton v Lowerhouse.
Meanwhile, in the Twenty20 competition, Nelson and Colne are in the Pride of Pendle group, alongside Bacup, Haslingden, Lowerhouse, Burnley and Church.
The group stages will be held over seven Friday evenings from May 29th, with semi-finals on July 17th and the final a week later on the 24th.
In the opening game of the Lancashire League season, on Sunday, April 19th, Nelson face a trip to Church, while Colne are at home to Accrington.
The derby games are on May 31st at the Horsfield and on August 30th at Seedhill.