Vincent Kompany’s men were beaten 3-1 by Liverpool last time out, despite producing an encouraging display in front of a record crowd at Anfield.
Lyle Foster has now joined Jordan Beyer, Luca Koleosho and Nathan Redmond on the sidelines, yet Charlie Taylor is expected to return to contention.
With that in mind, here’s how we think the Clarets could line up against Mikel Arteta’s side:
1. GK - James Trafford
Arsenal have been a huge threat from set pieces this season, so Trafford will need to be a lot more commanding of his box than he's been in recent weeks. Photo: Justin Setterfield
2. RB - Lorenz Assignon
The January recruit will be looking to build on what has been an impressive start to life at Turf Moor. Photo: Justin Setterfield
3. CB - Dara O'Shea
O'Shea performed well at Anfield last week, even scoring his first Premier League goal just before half-time. Photo: IAN HODGSON
4. CB - Maxime Esteve
The defender came off with a knock late on against Liverpool, but hopefully he's able to shake it off in time to face Arsenal. Photo: Justin Setterfield