Vincent Kompany’s men will be desperate to end their run of 10 games without a win and in turn, boost their fading survival chances.
As it stands, the Clarets sit 10 points adrift of safety with only 10 games remaining.
Kompany is likely to be without a number of players through injury, with Jordan Beyer, Ameen Al-Dakhil, Han-Noah Massengo, Aaron Ramsey, Luca Koleosho, Nathan Redmond and Lyle Foster all unavailable in recent weeks.
With that in mind, here’s how we think the Clarets might line up against Brentford:
1. GK - James Trafford
The only player to have started every league game for the Clarets this season. Photo: Julian Finney
2. RB - Lorenz Assignon
Appears to have that right-back spot nailed down following his arrival during the January transfer window. Photo: Justin Setterfield
3. CB - Dara O'Shea
Defended pretty solidly against West Ham last week, but the Clarets could do with a rare clean sheet this weekend. Photo: Matt McNulty
4. CB - Maxime Esteve
Will need to be switched on for the full 90 minutes following his costly error for West Ham's first goal last week. Photo: Julian Finney