It will be the first time that the two sides have met at Turf Moor in the top flight since September 1975.
The visitors won 1-0 on that occasion with Trevor Cherry scoring the winning goal midway through the first half.
The Whites won by the same scoreline at Elland Road earlier this term when Patrick Bamford, who was on loan with the Clarets three seasons ago, netted the decisive goal from the spot.
Burnley have won the last three league meetings at Turf Moor - with the first of those coming in Sean Dyche's second game in charge.
The hosts are without a win in nine games on their own patch in all competitions while Marcelo Bielsa's side have won two of their last three on the road, including against champions Manchester City.
Ahead of the match we've compared the two squads and drawn up a combined XI, according to WhoScored's ratings this season.
Here's how the team would line up in a 4-4-2 formation.
The Whites won by the same scoreline at Elland Road earlier this term when Patrick Bamford, who was on loan with the Clarets three seasons ago, netted the decisive goal from the spot.
5. Centre back: Liam Cooper (7.02)
Leeds captain Liam Cooper in action during the Premier League match between Leeds United and Crystal Palace at Elland Road on February 08, 2021 in Leeds, England. Photo: Stu Forster
6. Right midfield: Raphinha (7.18)
Bertrand Traore of Aston Villa is challenged by Raphinha of Leeds United during the Premier League match between Leeds United and Aston Villa at Elland Road on February 27, 2021 in Leeds, England. Photo: Laurence Griffiths
7. Left midfield: Jack Harrison (6.91)
Leeds United's English midfielder Jack Harrison (C) vies for the ball against Tottenham Hotspur's Ivorian defender Serge Aurier (R) during the English Premier League football match at Elland Road in Leeds, northern England on May 8, 2021. Photo: Oli Scarff
8. Centre midfield: Josh Brownhill (6.80)
Ruben Loftus-Cheek of Fulham battles for possession with Josh Brownhill of Burnley during the Premier League match between Fulham and Burnley at Craven Cottage on May 10, 2021 in London, England. Photo: Catherine Ivill