There's plenty riding on the outcome of the fixture in SW6 with Premier League survival at stake.
The Cottagers have won just two games on their own patch all season - against West Brom and Sheffield United - and have lost seven of their last 10 there.
Burnley meanwhile, have come out on top in half of their last eight games on the road.
Sean Dyche's side have beaten Liverpool, Crystal Palace, Everton and Wolves, conceding just once in those games.
Ahead of the match, which could see Fulham relegated back to the Championship, we've compared the two sides and drawn up a combined XI, according to WhoScored's ratings this season.
Here's how the team would line up in a 4-4-2 formation.
1. Goalkeeper: Nick Pope (6.82)
Burnley's English goalkeeper Nick Pope makes a save during the English Premier League football match between West Bromwich Albion and Burnley at The Hawthorns stadium in West Bromwich, central England, on October 19, 2020.
Photo: Tim Keeton
2. Right back: Kenny Tete (6.74)
Manchester City's Argentinian striker Sergio Aguero (L) challenges Fulham's Dutch defender Kenny Tete during the English Premier League football match between Fulham and Manchester City at Craven Cottage in London on March 13, 2021.
Photo: Catherine Ivill
3. Left back: Antonee Robinson (6.83)
Andros Townsend of Crystal Palace battles for possession with Antonee Robinson of Fulham during the Premier League match between Crystal Palace and Fulham at Selhurst Park on February 28, 2021 in London, England.
Photo: Mike Hewitt
4. Centre-back: James Tarkowski (7.03)
James Tarkowski of Burnley battles for possession with Said Benrahma of West Ham United during the Premier League match between Burnley and West Ham United at Turf Moor on May 03, 2021 in Burnley, England.
Photo: Jon Super